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Zebrafish Nk-lysins: First insights about their cellular and functional diversification

AutorPereiro, Patricia ; Varela, Mónica ; Díaz-Rosales, Patricia ; Romero, Alejandro ; Figueras Huerta, Antonio; Novoa, Beatriz
Palabras claveNk-lysin
Fecha de publicación2015
CitaciónDevelopmental and Comparative Immunology 51(1): 148-159 (2015)
ResumenNk-lysins are antimicrobial proteins produced by cytotoxic T lymphocytes and natural killer cells with a broad antimicrobial spectrum (including bacteria, fungi and parasites). Nevertheless, the implication of these proteins in the protection against viral infections is still poorly understood. In this work, four different Nk-lysin genes (nkla, nklb, nklc and nkld) were identified in the zebrafish genome. That means that zebrafish is the species with the higher repertoire of Nk-lysin genes described so far. The differential expression pattern of the Nk-lysins in several tissues, during ontogeny, among the different kidney cell populations, as well as between Rag1−/− and Rag1+/+ individuals, could suggest a certain specialization of different cell types in the production of different Nk-lysin. Moreover, only two of these genes (nkla and nkld) were significantly up-regulated after viral infection, and this observation could be also a consequence of a functional diversification of the zebrafish Nk-lysins
Descripción12 páginas, 9 figuras
Versión del editorhttp://dx.doi.org/10.1016/j.dci.2015.03.009
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