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Title

Zebrafish Nk-lysins: First insights about their cellular and functional diversification

AuthorsPereiro, Patricia ; Varela, Mónica ; Díaz-Rosales, Patricia ; Romero Jódar, Alejandro ; Figueras Huerta, Antonio ; Novoa, Beatriz
KeywordsNk-lysin
Granulysin
Zebrafish
Rag1
Ontogeny
SVCV
Issue Date2015
PublisherElsevier
CitationDevelopmental and Comparative Immunology 51(1): 148-159 (2015)
AbstractNk-lysins are antimicrobial proteins produced by cytotoxic T lymphocytes and natural killer cells with a broad antimicrobial spectrum (including bacteria, fungi and parasites). Nevertheless, the implication of these proteins in the protection against viral infections is still poorly understood. In this work, four different Nk-lysin genes (nkla, nklb, nklc and nkld) were identified in the zebrafish genome. That means that zebrafish is the species with the higher repertoire of Nk-lysin genes described so far. The differential expression pattern of the Nk-lysins in several tissues, during ontogeny, among the different kidney cell populations, as well as between Rag1−/− and Rag1+/+ individuals, could suggest a certain specialization of different cell types in the production of different Nk-lysin. Moreover, only two of these genes (nkla and nkld) were significantly up-regulated after viral infection, and this observation could be also a consequence of a functional diversification of the zebrafish Nk-lysins
Description12 páginas, 9 figuras
Publisher version (URL)http://dx.doi.org/10.1016/j.dci.2015.03.009
URIhttp://hdl.handle.net/10261/114892
DOI10.1016/j.dci.2015.03.009
ISSN0145-305X
E-ISSN1879-0089
Appears in Collections:(IIM) Artículos
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