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Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility

AuthorsAlcázar-Fuoli, Laura; Mellado, Emilia; García-Effron, Guillermo; Buitrago, María J.; López, Jordi F.; Grimalt, Joan O. ; Cuenca-Estrella, J. Manuel; Rodriguez-Tudela, Juan L.
Fungi Imperfecti
Drug susceptibility test
Antifungal agent
Aspergillus fumigatus
Issue DateFeb-2006
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemoteraphy 50(2): 453-460 (2006)
AbstractTwo erg3 genes encoding C-5 sterol desaturase enzymes (Erg3A and Erg3B) in Aspergillus fumigatus were characterized with respect to their nucleotide sequences and null mutant phenotypes. Targeted disruption of the erg3A and erg3B genes and a double gene knockout, erg3A– erg3B–, showed that they are not essential for A. fumigatus viability. Mutant phenotypes clearly showed that Erg3B is a C-5 sterol desaturase, but no apparent role for Erg3A in A. fumigatus ergosterol biosynthesis was found. Susceptibility to amphotericin B, itraconazole, fluconazole, voriconazole, and ketoconazole was not altered in isolates in which erg3A and erg3B were knocked out alone and in combination.
Description8 pages, 3 tables, 2 figures.-- PMID: 16436696 [PubMed].-- PMCID: PMC1366924.
Publisher version (URL)http://dx.doi.org/10.1128/AAC.50.2.453-460.2006
Appears in Collections:(IDAEA) Artículos
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