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Production of supercritical Rosemary extracts and their effect on tumor progression

AutorVicente, G. ; Molina, Susana; González-Vallinas, Margarita; García-Risco, Mónica R. ; Fornari, Tiziana ; Reglero, Guillermo ; Ramírez de Molina, Ana
Fecha de publicación2012
CitaciónISSF 2012
ResumenSupercritical fluid technology is the most innovative method to recover bioactive compounds for use as supplements for functional foods. Particularly, the recovery of antioxidant compounds from different herbs is being a matter of continuous research and development. Besides their role as food stabilizers, antioxidants can protect cells against the effects of free radicals and thus, play an important role in heart disease, cancer and other diseases. Rosemary (Rosmarinus officinalis L.) has been recognized as one of the Lamiaceae plant with large antioxidant activity. Main substances associated with the antioxidant activity are the phenolic diterpenes such as carnosol, rosmanol, carnosic acid, methyl carnosate, and phenolic acids such as the rosmarinic and caffeic acids. Particularly, carnosic acid is accepted as the most abundant antioxidant present in rosemary. In this work, supercritical fluid technology was applied to produce rosemary extracts with different composition (phenolic compounds and volatile oil content) and thus, with different antioxidant power. For this purpose, pure CO2 and CO2 modified with ethanol were utilized as supercritical solvents, and diverse extraction conditions (temperature, pressure, amount of cosolvent and fractionation procedure) were applied. Selected extracts, from the variety of samples obtained, were used to study the capability of rosemary supercritical extracts to inhibit the proliferation of human liver carcinoma cells. Moreover, the cytostatic effect of the different selected extracts were determined, revealing a dose-dependent effect of the different compositions of the extracts on the response of human hepatocarcinoma cells to the potential antitumoral effect of rosemary.
DescripciónTrabajo presentado al 10th International Symposium on Supercritical Fluids celebrado en San Francisco (US) del 13 al 16 de mayo de 2012.
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