English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/114697
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: Implications for alzheimer's disease

AutorLlorens-Martín, M. ; Texeira, Cátia M.; Fuster-Matanzo, Almudena ; Jurado-Arjona, Jerónimo ; Borrell, V.; Soriano, Eduardo; Ávila, Jesús ; Hernández Pérez, Félix
Palabras claveDentate gyrus
Subgranular zone
Tau protein
Adult neurogenesis
Fecha de publicación2012
EditorIOS Press
CitaciónJournal of Alzheimer's Disease 29: 921- 930 (2012)
ResumenIn the adult hippocampal dentate gyrus, newborn granule cells grow dendrites into the molecular layer and send axons into the CA3 region. Several molecular markers have been used to analyze production of these new neurons; however, no good markers for new axons have been described. Here we demonstrate that tau protein isoform with three microtubule binding domains (3R-Tau) is a marker of those axons following an antigen retrieval protocol. By using retrovirus-mediated GFP transduction, GFP can be detected in a period of 7-14 days after viral infection. We also provide a >proof of principle> demonstration of the power of that labeling showing modulation of 3R-Tau positive axons under physiological conditions (exercise and aging) as well as in a FTDP-17 neurodegenerative model and Alzheimer's disease models (mice overexpressing AβPPsw, ind or GSK3β). We conclude that 3R-Tau would be an efficient marker and a valuable tool to study new axons in adult neurogenesis as well as in neurodegenerative processes. © 2012-IOS Press and the authors. All rights reserved.
URIhttp://hdl.handle.net/10261/114697
DOI10.3233/JAD-2012-112057
Identificadoresdoi: 10.3233/JAD-2012-112057
issn: 1387-2877
Aparece en las colecciones: (CBM) Artículos
(IN) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
J_Avila_Tau_Isoform.pdf908,55 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.