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Título

Role of protease-activated receptor 2 in lung injury development during acute pancreatitis in rats

Autor Madaria, Enrique de; Francés, María del Mar; Gea-Sorlí, Sabrina ; Gutiérrez, Luis M.; Viniegra, Salvador; Pérez-Mateo, Miguel; Closa, Daniel ; López-Font, Inmaculada
Palabras clave trypsin
PAR receptors
Pancreatitis
Mast cells
Macrophages
Lung injury
Fecha de publicación ago-2014
EditorLippincott Williams & Wilkins
Citación Pancreas 43(6): 895-902 (2014)
ResumenObjective: The objective of this study was to evaluate whether an uncontrolled activation of mast cells and macrophages through protease-activated receptor-2 (PAR-2) during acute pancreatitis could develop lung injury. Methods: Pancreatitis was induced in rats by intraductal infusion of sodium taurocholate. In a group of animals, PAR-2 antagonist or trypsin (TRP) inhibitor was intravenously administered before the pancreatitis induction. In additional groups, the animals were treated with PAR-2-activating peptide or pancreatic TRP. The myeloperoxidase (MPO) activity was measured to evaluate the progression of inflammation. Results: Plasma from the animals with pancreatitis and pancreatic TRP induced the secretion of mast cells and alveolar macrophages as well as increased the density of PAR-2 in the plasma membrane. The treatment of alveolar macrophages with TRP, tryptase, as well as PAR-1- and PAR-2-activating peptide led to an increase in calcium-triggered exocytosis. Similar results were obtained in acinar cells. The intravenous injection of PAR-2-activating peptide and TRP induced an increase in MPO activity in the lung. The intravenous injection of PAR-2 antagonist or TRP inhibitor before the pancreatitis induction could prevent the increase in MPO activity in the pancreas and the lung. Conclusions: The TRP generated during acute pancreatitis could be involved in the progression of lung injury through the activation of PAR-2 in alveolar macrophages. Copyright © 2014 Lippincott Williams & Wilkins.
Versión del editorhttp://dx.doi.org/10.1097/MPA.0000000000000152
URI http://hdl.handle.net/10261/114665
DOI10.1097/MPA.0000000000000152
Identificadoresdoi: 10.1097/MPA.0000000000000152
issn: 1536-4828
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