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Título

Studies on aromatic compounds: inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids

AutorMontero, Ana; Alonso Giner, Mercedes; Benito Cano, Esperanza ; Chana López, Antonio ; Mann, Enrique ; Navas, José M.; Herradón García, Bernardo
Palabras claveCalpain inhibitor
Biphenyl
Peptide-biphenyl hybrids
Aromatic compounds
Fecha de publicación23-abr-2004
EditorElsevier
CitaciónBioorganic & Medicinal Chemistry Letters 14(11): 2753-2757 (2004)
ResumenWith the objective to understand structural features responsible for the biological activity, novel nonelectrophilic biphenyl derivatives and peptide-biphenyl hybrids have been synthesized and evaluated as calpain I inhibitors. The preliminary results indicate that the presence of additional aromatic rings (besides the biphenyl system) makes these compounds potent calpain inhibitors with IC50 values in the nanomolar range.
Descripción5 pages, 2 figures, 1 table, 2 schemes.-- PMID: 15125927 [PubMed].-- Printed version published Jun 7, 2004.
Taken in part from the Ph. D. thesis of AC (Complutense University, Madrid, 2003) and the projected Ph. D. thesis of AM and MA. Spanish patent ES-P200301125 was filed as of Feb 16, 2006.
Versión del editorhttp://dx.doi.org/10.1016/j.bmcl.2004.03.071
URIhttp://hdl.handle.net/10261/11457
DOI10.1016/j.bmcl.2004.03.071
ISSN0960-894X
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