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Título

Circulating TNF-α and its soluble receptors during experimental acute pancreatitis

AutorGranell, Susana; Pereda, Javier; Gómez-Cambronero, Luis G.; Cassinello, Norberto; Sabater, Luis; Closa, Daniel ; Sastre, Juan
Palabras claveSIRS
Inflammation
TNF-α
sTNF-αR
Pancreatitis
Fecha de publicación21-feb-2004
EditorAcademic Press
CitaciónCytokine 25(4): 187-191 (2004)
ResumenClinical and experimental studies have shown increased concentrations of TNF-α and its soluble receptors in serum of patients with acute pancreatitis. In this work, we have investigated the time-course of TNF-α and its soluble receptors during taurocholate-induced acute pancreatitis. In addition, since TNF-α itself could mediate the shedding of its receptors, we have assessed the effect of inhibiting TNF-α production on the release of soluble TNF-α receptors in experimental acute pancreatitis. Our results indicate that soluble receptors are released in the early stages of the disease and this increase is concomitant with the release of TNF-α, which is mainly bound to specific proteins. The increased concentrations of its receptors strongly suggest that they could be these binding proteins. Inhibition of TNF-α generation with pentoxifylline abrogated the shedding of sTNF-αR1, but had no effect on sTNF-αR2. This finding suggests that the shedding of sTNF-αR1 is induced by TNF-α itself, but in the case of sTNF-αR2, the shedding appears to be induced by another mechanism. © 2003 Elsevier Ltd. All rights reserved.
Versión del editorhttp://dx.doi.org/10.1016/j.cyto.2003.10.011
URIhttp://hdl.handle.net/10261/114499
DOI10.1016/j.cyto.2003.10.011
Identificadoresdoi: 10.1016/j.cyto.2003.10.011
issn: 1043-4666
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