Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/114355
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | RNA structural elements of hepatitis C virus controlling viral RNA translation and the implications for viral pathogenesis |
Autor: | Piñeiro, David; Martínez-Salas, Encarnación CSIC ORCID | Palabras clave: | Hepatitis C Host factors IRES RNA structural elements Translation control |
Fecha de publicación: | 2012 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | VIRUSES 4: 2233- 2250 (2012) | Resumen: | Hepatitis C virus (HCV) genome multiplication requires the concerted action of the viral RNA, host factors and viral proteins. Recent studies have provided information about the requirement of specific viral RNA motifs that play an active role in the viral life cycle. RNA regulatory motifs controlling translation and replication of the viral RNA are mostly found at the 5' and 3' untranslated regions (UTRs). In particular, viral protein synthesis is under the control of the internal ribosome entry site (IRES) element, a complex RNA structure located at the 5'UTR that recruits the ribosomal subunits to the initiator codon. Accordingly, interfering with this RNA structural motif causes the abrogation of the viral cycle. In addition, RNA translation initiation is modulated by cellular factors, including miRNAs and RNA-binding proteins. Interestingly, a RNA structural motif located at the 3'end controls viral replication and establishes long-range RNA-RNA interactions with the 5'UTR, generating functional bridges between both ends on the viral genome. In this article, we review recent advances on virus-host interaction and translation control modulating viral gene expression in infected cells. | URI: | http://hdl.handle.net/10261/114355 | DOI: | 10.3390/v4102233 | Identificadores: | doi: 10.3390/v4102233 issn: 1999-4915 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
E_Martinez_Salas_RNA_Structural.pdf | 477,21 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
21
checked on 14-mar-2024
SCOPUSTM
Citations
33
checked on 20-mar-2024
WEB OF SCIENCETM
Citations
29
checked on 29-feb-2024
Page view(s)
234
checked on 28-mar-2024
Download(s)
231
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.