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Título

ASIA syndrome in sheep; Molecular characterization of activation molecules in peripheral blood mononuclear cells after repeated vaccinations

Autor Luján, Lluís; Insausti, N.; Pablo, Lorena de ; Gimeno, Marina; Pinczowski, Pedro; Sanjosé, Leticia ; Pérez, Marta M.; Andrés, Damián F. de ; Amorena Zabalza, Beatriz ; Reina, Ramsés
Fecha de publicación mar-2014
Citación 9th International Congress on Autoimmunity (2014)
ResumenASIA (Autoimmune/inflammatory syndrome induced by adjuvants) syndrome in sheep is characterized by acute and/or chronic affection of animals after repeated application of aluminum-containing vaccines, with a devastating outcome in affected sheep. The study of the monocyte-macrophage lineage is a key step to understand the immune reaction triggered by aluminum. This study characterizes the ex vivo effect on peripheral blood mononuclear cells (PBMC) differentiation (M1 vs. M2) observed after serial administration of aluminum-based vaccines. Five sheep affected by the chronic phase of the ASIA syndrome (Group B) and two non-affected control animals (Group A) were used. One of the two control animals was naturally infected by Visna/maedi virus (VMV), an ovine lentiviral infection. All animals were vaccinated four times over a period of 56 days, each individual receiving a total of 36 mg of AlOH3. Results demonstrated that in group B, marker molecules of M1 differentiation pathway (A3Z1 and TNFa) significantly increased their expression along the course of the experiment. M2 molecules (MR and DC-SIGN) showed an increased relative expression at the end of the experiment but to a much lesser degree. One animal in group B developed the acute phase of ASIA at 19 dpi. The VMV-infected animal in group A suffered a disease reactivation characterized by acute arthritis. Lesions demonstrated a severe neurodegeneration mainly in the lumbar spinal cord. This is the first scientific work that contributes to understand on the systemic effects of AlOH3-containing vaccines in sheep. Results show a wide range of molecular immune effects that may help to understand the pathogenesis of ovine ASIA syndrome.
Descripción Trabajo presentado en el 9th International Congress on Autoimmunity, celebrado en Niza del 26 al 30 de marzo de 2014.
URI http://hdl.handle.net/10261/114286
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