English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/114237
Título

Polycomb Controls Gliogenesis by Regulating the Transient Expression of the Gcm/Glide Fate Determinant

AutorPopkova, Anna; Bernardoni, Roberto; Diebold, Celine; Bor, Véronique van de; Schuettengruber, Bernd; González, Inma; Busturia, Ana; Cavalli, Giacomo; Giangrande, A.
Fecha de publicación2012
EditorPublic Library of Science
CitaciónPLoS Genetics 8 (12): e1003159 (2012)
ResumenThe Gcm/Glide transcription factor is transiently expressed and required in the Drosophila nervous system. Threshold Gcm/Glide levels control the glial versus neuronal fate choice, and its perdurance triggers excessive gliogenesis, showing that its tight and dynamic regulation ensures the proper balance between neurons and glia. Here, we present a genetic screen for potential gcm/glide interactors and identify genes encoding chromatin factors of the Trithorax and of the Polycomb groups. These proteins maintain the heritable epigenetic state, among others, of HOX genes throughout development, but their regulatory role on transiently expressed genes remains elusive. Here we show that Polycomb negatively affects Gcm/Glide autoregulation, a positive feedback loop that allows timely accumulation of Gcm/Glide threshold levels. Such temporal fine-tuning of gene expression tightly controls gliogenesis. This work performed at the levels of individual cells reveals an undescribed mode of Polycomb action in the modulation of transiently expressed fate determinants and hence in the acquisition of specific cell identity in the nervous system. © 2012 Popkova et al.
URIhttp://hdl.handle.net/10261/114237
DOI10.1371/journal.pgen.1003159
Identificadoresdoi: 10.1371/journal.pgen.1003159
issn: 1553-7390
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
A_Busturia_Polycomb.pdf6,04 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.