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The cytotoxic effects of Bowman-Birk proteins from legumes on colon cancer cells are related to their ability to inhibit serine proteases

AuthorsClemente, Alfonso; Marín-Manzano, M. Carmen; Jiménez, E.; Sonnante, G.; Moreno, F. Javier ; Rubio, Luis A. ; Domoney, C.
Issue Date2010
CitationV IFLRC (2010)
VII AEP (2010)
AbstractColon cancer is the second most common cause of death from cancer within the EU. One of the most effective means of preventing or reducing colon cancer risk is either directly or indirectly linked to appropriate diet. Naturally-occurring protease inhibitors (PI) of the Bowman-Birk family, a major PI class in legumes such as soybean, pea, lentil and chickpea, have been linked to a possible protective effect against inflammation and cancer development within the gastrointestinal tract (GIT). Bowman-Birk inhibitors (BBI) have been shown to be structurally and functionally resistant to the challenges of the GIT in vivo (Marín-Manzano et al., 2009). In addition, we have demonstrated that soybean (Clemente et al., 2010) and lentil (Cappialupi et al., 2010) BBI proteins exert an anti-proliferative effect on HT29 colon adenocarcinoma cells in a dose-dependent manner, whereas non-malignant colonic fibroblast CCD-18Co cells were unaffected. Interestingly, chemically inactivated soybean BBI had a weak but non-significant effect on the proliferation of HT29 colon cancer cells. These data clearly suggest that the anti-proliferative activity of BBI proteins on colorectal cancer cells is mediated via protease inhibition. The action mechanisms of these effects remain unknown; their elucidation will provide insights into the properties of BBI proteins as colorectal chemopreventive agents, providing a strong base for the development of European legume crops and their products as pro-nutritional, health-promoting food.
DescriptionResumen del trabajo presentado al 5th International Food Legumes Research Conference (IFLRC V) y al 7th European Conference on Grain Legumes celebrados en Antalya (Turquia) del 26 al 30 de abril de 2010.
Appears in Collections:(EEZ) Comunicaciones congresos
(IFI) Comunicaciones congresos
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