English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/114134
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Peripheral cholesterol, metabolic disorders and Alzheimer's disease

AutorLedesma, M. Dolores ; Dotti, Carlos G.
Palabras claveBrain blood barrier
Leptin
Insulin
Atherosclerosis
Review
Hypercholesterolemia
Diabetes
Obesity
Alzheimer's disease
Fecha de publicación2012
EditorFrontiers in Bioscience Publications
CitaciónFrontiers in Bioscience (Elite edition) 4: 181- 194 (2012)
ResumenStrong correlations have been made between high levels of blood cholesterol and the risk to suffer Alzheimer's disease (AD). The question arises on how a peripheral event contributes to a disease that so severely affects the integrity and function of the Central Nervous System. Hypercholesterolemia has been also associated to peripheral metabolic disorders like diabetes, obesity or atherosclerosis that, in turn, predispose to AD. Here we review data, which point to alterations in blood cholesterol levels as a link between these metabolic disorders and AD. We describe and discuss common, cholesterol-related, molecular mechanisms and strategies to fight these conditions that, altogether, constitute a major cause of death in our societies.
URIhttp://hdl.handle.net/10261/114134
Identificadoresissn: 1945-0508
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.