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http://hdl.handle.net/10261/114105
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dc.contributor.author | Tacchini, Lorenza | - |
dc.contributor.author | Cairo, Gaetano | - |
dc.contributor.author | De Ponti, Cristina | - |
dc.contributor.author | Massip-Salcedo, Marta | - |
dc.contributor.author | Roselló-Catafau, Joan | - |
dc.contributor.author | Peralta, Carmen | - |
dc.date.accessioned | 2015-04-23T11:34:48Z | - |
dc.date.available | 2015-04-23T11:34:48Z | - |
dc.date.issued | 2006-11 | - |
dc.identifier | doi: 10.1080/10715760600885432 | - |
dc.identifier | issn: 1071-5762 | - |
dc.identifier.citation | Free Radical Research 40(11): 1206-1217 (2006) | - |
dc.identifier.uri | http://hdl.handle.net/10261/114105 | - |
dc.description.abstract | We analyzed the role of IL-6 in the protection that ischemic preconditioning (IP) exerts against hepatic ischemia reperfusion-mediated (I/R) oxidative damage, particularly in fatty livers. IP-related IL-6 up-regulation during reperfusion in steatotic and non-steatotic livers was correlated with reduced indices of liver damage, as also demonstrated by pharmacological modulation of IL-6. IP activated NF-κB and HSF during ischemia (Isc), whereas AP-1 activity was unaffected. IP blunted the activation of STAT3 and stress-responsive genes, such as NF-κB, AP-1 and heme oxygenase (HO-1) during reperfusion. The role of reduced oxidative stress in hepatoprotection of fatty livers was further demonstrated by the fact that: (i) IP prevented the decrease of glutathione levels and the increase of lipid peroxidation; (ii) the anti-oxidant GSH-ester prevented lipid peroxidation and necrosis. In conclusion, IP modulates the activity of transcription factors and triggers IL-6 production; this may prevent hepatic I/R damage in a oxidative stress-dependent way, particularly in fatty livers. | - |
dc.publisher | Taylor & Francis | - |
dc.rights | closedAccess | - |
dc.subject | Oxidative stress | - |
dc.subject | Redox reactions | - |
dc.subject | Transcription factors | - |
dc.subject | Reperfusion | - |
dc.title | Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: Association with reduction of oxidative stress | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1080/10715760600885432 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1080/10715760600885432 | - |
dc.date.updated | 2015-04-23T11:34:49Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
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