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Título

Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: Association with reduction of oxidative stress

AutorTacchini, Lorenza; Cairo, Gaetano; De Ponti, Cristina; Massip-Salcedo, Marta ; Roselló-Catafau, Joan ; Peralta, Carmen
Palabras claveOxidative stress
Redox reactions
Transcription factors
Reperfusion
Fecha de publicaciónnov-2006
EditorTaylor & Francis
CitaciónFree Radical Research 40(11): 1206-1217 (2006)
ResumenWe analyzed the role of IL-6 in the protection that ischemic preconditioning (IP) exerts against hepatic ischemia reperfusion-mediated (I/R) oxidative damage, particularly in fatty livers. IP-related IL-6 up-regulation during reperfusion in steatotic and non-steatotic livers was correlated with reduced indices of liver damage, as also demonstrated by pharmacological modulation of IL-6. IP activated NF-κB and HSF during ischemia (Isc), whereas AP-1 activity was unaffected. IP blunted the activation of STAT3 and stress-responsive genes, such as NF-κB, AP-1 and heme oxygenase (HO-1) during reperfusion. The role of reduced oxidative stress in hepatoprotection of fatty livers was further demonstrated by the fact that: (i) IP prevented the decrease of glutathione levels and the increase of lipid peroxidation; (ii) the anti-oxidant GSH-ester prevented lipid peroxidation and necrosis. In conclusion, IP modulates the activity of transcription factors and triggers IL-6 production; this may prevent hepatic I/R damage in a oxidative stress-dependent way, particularly in fatty livers.
Versión del editorhttp://dx.doi.org/10.1080/10715760600885432
URIhttp://hdl.handle.net/10261/114105
DOI10.1080/10715760600885432
Identificadoresdoi: 10.1080/10715760600885432
issn: 1071-5762
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