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Título: | P-selectin upregulation in bleomycin induced lung injury in rats: Effect of N-acetyl-L-cysteine |
Autor: | Serrano-Mollar, Anna CSIC ORCID; Closa, Daniel CSIC ORCID; Cortijo, Julio; Morcillo, Esteban J.; Prats, Neus; Gironella, Meritxell; Panés, Julián; Roselló-Catafau, Joan CSIC ORCID; Bulbena, Oriol CSIC | Fecha de publicación: | 2002 | Editor: | BMJ Publishing Group | Citación: | Thorax 57(7): 629-634 (2002) | Resumen: | Background: A number of adhesion molecules are involved in the process of neutrophil infiltration into the lung. P-selectin is one of these neutrophil-endothelial cell adhesion molecules. A study was undertaken to examine the involvement of P-selectin in the development of bleomycin induced inflammation and the ability of N-acetyl-L-cysteine to reduce the potential expression of this selectin in rats. Methods: N-acetyl-L-cysteine (3 mmol/kg po) was administered daily for seven days prior to bleomycin administration (2.5 U/kg). The kinetics of P-selectin expression and the effect of N-acetyl-L-cysteine after bleomycin treatment were measured using radiolabelled antibodies. P-selectin localisation was evaluated by immunohistochemistry and neutrophil infiltration was assessed by myeloperoxidase activity. Results: Bleomycin administration resulted in an upregulation of P-selectin at 1 hour, returning to baseline at 3 hours. Myeloperoxidase activity showed a significant increase at 6 hours after bleomycin administration that lasted for 3 days. N-acetyl-L-cysteine treatment completely prevented these increases. Conclusion: Upregulation of P-selectin in the lung is associated with neutrophil recruitment in response to bleomycin. The beneficial effect of N-acetyl-L-cysteine on bleomycin induced lung injury may be explained in part by the prevention of neutrophil recruitment in the inflammatory stage of the disease. | Versión del editor: | http://dx.doi.org/10.1136/thorax.57.7.629 | URI: | http://hdl.handle.net/10261/114085 | DOI: | 10.1136/thorax.57.7.629 | Identificadores: | doi: 10.1136/thorax.57.7.629 issn: 0040-6376 |
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