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P-selectin expression and Kupffer cell activation in rat acute pancreatitis

AuthorsFolch-Puy, Emma ; Prats, Neus; Hotter, Georgina ; López, Santiago; Gelpí, Emili ; Roselló-Catafau, Joan ; Closa, Daniel
Issue Date2000
PublisherKluwer Academic/Plenum Publishers
CitationDigestive Diseases and Sciences 45(8): 1535-1544 (2000)
AbstractThis work studied the activation of hepatic macrophages during acute pancreatitis and the involvement of these cells in the lung inflammatory response. Pancreatitis was induced in Wistar rats by intraductal administration of 5% sodium taurocholate. Three hours after pancreatitis induction, the degree of pulmonary inflammation, TNF-α levels, and P-selectin expression were evaluated. The generation of TNF-α by Kupffer cells was also measured. Pancreatitis increases the serum concentration of TNF-α, neutrophil infiltration, and P-selectin expression in pancreas and lung. In addition, Kupffer cells generate increased levels of TNF-α. When Kupffer cells were inhibited, the increase in serum TNF-α levels and the infiltration of neutrophils in the lung were prevented, but P-selectin expression remained unmodified. We conclude that pulmonary inflammation induced by acute pancreatitis is mediated by Kupffer cell activation and that pancreatitis induces the expression of P-selectin on pulmonary endothelial cells but this effect is not mediated by Kupffer cells.
Publisher version (URL)http://dx.doi.org/10.1023/A:1005552725243
Identifiersdoi: 10.1023/A:1005552725243
issn: 0163-2116
Appears in Collections:(IIBB) Artículos
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