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Título

P-selectin expression and Kupffer cell activation in rat acute pancreatitis

AutorFolch-Puy, Emma ; Prats, Neus; Hotter, Georgina ; López, Santiago; Gelpí, Emili ; Roselló-Catafau, Joan ; Closa, Daniel
Palabras claveInflammation
ARDS
Taurocholate
Fecha de publicación2000
EditorKluwer Academic/Plenum Publishers
CitaciónDigestive Diseases and Sciences 45(8): 1535-1544 (2000)
ResumenThis work studied the activation of hepatic macrophages during acute pancreatitis and the involvement of these cells in the lung inflammatory response. Pancreatitis was induced in Wistar rats by intraductal administration of 5% sodium taurocholate. Three hours after pancreatitis induction, the degree of pulmonary inflammation, TNF-α levels, and P-selectin expression were evaluated. The generation of TNF-α by Kupffer cells was also measured. Pancreatitis increases the serum concentration of TNF-α, neutrophil infiltration, and P-selectin expression in pancreas and lung. In addition, Kupffer cells generate increased levels of TNF-α. When Kupffer cells were inhibited, the increase in serum TNF-α levels and the infiltration of neutrophils in the lung were prevented, but P-selectin expression remained unmodified. We conclude that pulmonary inflammation induced by acute pancreatitis is mediated by Kupffer cell activation and that pancreatitis induces the expression of P-selectin on pulmonary endothelial cells but this effect is not mediated by Kupffer cells.
Versión del editorhttp://dx.doi.org/10.1023/A:1005552725243
URIhttp://hdl.handle.net/10261/114084
DOI10.1023/A:1005552725243
Identificadoresdoi: 10.1023/A:1005552725243
issn: 0163-2116
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