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Título: | Pancreatitis induces HSP72 in the lung: Role of neutrophils and xanthine oxidase |
Autor: | Folch-Puy, Emma CSIC ORCID ; Closa, Daniel CSIC ORCID; Ñeco, Patricia; Solé, Sònia; Planas, Anna M. CSIC ORCID; Gelpí, Emili CSIC; Roselló-Catafau, Joan CSIC ORCID | Palabras clave: | Pancreatitis Neutrophil Oxypurinol ARDS HSP |
Fecha de publicación: | 14-jul-2000 | Editor: | Academic Press | Citación: | Biochemical and Biophysical Research Communications 273(3): 1078-1083 (2000) | Resumen: | The aim of this work was to evaluate the systemic Hsp72 expression in rat lung and liver in vivo in a model of acute pancreatitis and investigate the possible involvement of xanthine oxidase and neutrophils in this process. Pancreatitis was induced by intraductal administration of 5% sodium taurocholate and samples of lung and liver were obtained 1 and 3 h later. In some groups of rats circulating xanthine oxidase was inhibited with oxypurinol, and neutrophil recruitment was blocked with a monoclonal antibody against P-selectin. Hsp72 expression was assessed by means of Western blot and immunohistochemistry. Results showed Hsp72 induction in lung, but not in liver, shortly after pancreatitis. Hsp72-induced expression was located in bronchial epithelium, alveolar macrophages, infiltrating neutrophils, and blood vessels. Oxypurinol and the antibody against P-selectin prevented pancreatitis-induced lung Hsp72 overexpression suggesting that Hsp72 induction is mediated by neutrophil infiltration into the lungs. (C) 2000 Academic Press. | Versión del editor: | http://dx.doi.org/10.1006/bbrc.2000.3077 | URI: | http://hdl.handle.net/10261/114073 | DOI: | 10.1006/bbrc.2000.3077 | Identificadores: | doi: 10.1006/bbrc.2000.3077 issn: 0006-291X |
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