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Síndrome de isquemia-reperfusión asociado al trasplante hepático: Una visión actualizada

Other TitlesIschemia-reperfusion syndrome associated with liver transplantation: An update
AuthorsCasillas-Ramírez, Araní ; Mosbah, Ismail Ben ; Franco-Gou, Rosa ; Rimola, Antoni; Roselló-Catafau, Joan ; Peralta, Carmen
Issue DateMay-2006
PublisherElsevier España
CitationGastroenterologia y Hepatologia 29(5): 306-313 (2006)
AbstractIschemia-reperfusion (I/R) injury is the main cause of both initial graft dysfunction and primary failure in liver transplantation. The search for therapeutic strategies to prevent I/R injury has led to research into promising drugs, although most have not been used clinically. Gene therapy requires better transfection techniques, avoiding vector toxicity, and ethical debate before being used clinically. Ischemic preconditioning is the first therapeutic strategy used in clinical practice to reduce I/R injury in hepatectomies for tumors. Future research will provide data on the effectiveness of ischemic preconditioning in reducing I/R injury associated with liver transplantation, and in reducing the vulnerability of steatotic grafts to I/R syndrome so that they can be used in transplantation, thus relieving the organ shortage.
Publisher version (URL)http://dx.doi.org/10.1157/13087472
Identifiersdoi: 10.1157/13087472
issn: 0210-5705
Appears in Collections:(IIBB) Artículos
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