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Título

Endothelin mediated nitric oxide effects in ischemia-reperfusion associated with pancreas transplantation

Autor Hotter, Georgina ; Pi, Felip ; Sanz, Carles; Peralta, Carmen; Prats, Neus; Gelpí, Emili ; Badosa, Francisco; Fernández-Cruz, Laureano; Roselló-Catafau, Joan
Palabras clave Myeloperoxidase
Nitric oxide
Transplantation
Endothelin
Fecha de publicación 1998
EditorKluwer Academic/Plenum Publishers
Citación Digestive Diseases and Sciences 43(12): 2627-2633 (1998)
ResumenFormation of nitric oxide (NO) in ischemia-reperfusion (I-R) associated with pancreas transplantation could modulate the inflammatory response. In this sense, previous studies have demonstrated the action of NO on vasoactive substances like prostacyclin or endothelin. The present study was designed to evaluate the contribution of endothelin to the inflammatory events induced by NO in the I-R process associated with pancreas transplantation. For this purpose, pancreatic levels of endothelin, neutrophil infiltration, and prostacyclin were evaluated in an experimental model of pancreas transplantation after inhibition of NO synthesis or after NO inhibition plus addition of endothelin. Results show significant posttransplantation increases in endothelin, neutrophil infiltration, and prostacyclin production. These increases were prevented by NO inhibition. Endothelin administration plus nitric oxide inhibition reversed this effect, resulting in an increase in myeloperoxidase and 6-ketoprostaglandin F(1α). These results suggest that the proinflammatory effects of NO in I-R associated with pancreas transplantation are mediated by the induction of endothelin generation.
Versión del editorhttp://dx.doi.org/10.1023/A:1026690925081
URI http://hdl.handle.net/10261/114028
DOI10.1023/A:1026690925081
Identificadoresdoi: 10.1023/A:1026690925081
issn: 0163-2116
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