English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/114021
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Effect of peritoneal lavage and lymph ligature on systemic complications of experimental acute pancreatitis

AuthorsFolch-Puy, Emma ; Closa, Daniel ; Gelpí, Emili ; Roselló-Catafau, Joan
KeywordsInflammation
Lymph
Pancreatitis
Ascites
Issue Date2000
PublisherKluwer Academic/Plenum Publishers
CitationDigestive Diseases and Sciences 45(5): 909-914 (2000)
AbstractWe studied the involvement of ascitic fluid on the systemic effects of experimental acute pancreatitis. This has been achieved by comparing the effectiveness of either peritoneal lavage or lymphatic ligature on preventing changes in systemic vascular permeability. Three hours after induction of pancreatitis, we found increases in vascular permeability in the pancreas, lung, and intestine. Both peritoneal lavage and lymphatic ligature were able to prevent the changes observed in the lung and intestine and the increases on plasma levels of lipase and amylase, suggesting a similar involvement for lymphatic draining and peritoneal absorption pathways. In addition, we evaluated the effect of intraperitoneal deposition into health rats of pancreatitis-associated ascitic fluid collected from rats with experimental acute pancreatitis. A significant increase in plasma amylase and lipase levels could be observed but no changes in vascular permeability were found. Altogether, these results indicate that transperitoneal absorption of toxic mediators from the ascitic fluid is not enough to explain the systemic damage induced by acute pancreatitis.
Publisher version (URL)http_//dx.doi.org/10.1023/A:1005568923539
URIhttp://hdl.handle.net/10261/114021
DOI10.1023/A:1005568923539
Identifiersdoi: 10.1023/A:1005568923539
issn: 0163-2116
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.