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Título

Differential effect of nitric oxide inhibition as a function of preservation period in pancreas transplantation

Autor Pi, Felip ; Hotter, Georgina ; Closa, Daniel ; Prats, Neus; Fernández-Cruz, Laureano; Badosa, Francisco; Gelpí, Emili ; Roselló-Catafau, Joan
Palabras clave leukotriene B4
transplantation
nitric oxide
pancreas
prostaglandins
free radicals
Fecha de publicación 1997
EditorKluwer Academic/Plenum Publishers
Citación Digestive Diseases and Sciences 42(5): 962-971 (1997)
ResumenThe role of nitric oxide, produced during reperfusion as a function of preservation time, in the development of the inflammatory process in pancreas transplantation has been explored. For this purpose, the effect of nitric oxide synthase inhibition, as well as 6-keto-prostaglandin F(1α) leukotriene B4, and lipoperoxidation levels were evaluated in an experimental model of rat pancreas transplantation after different periods of cold preservation. The results show posttransplantation increases in 6-keto-prostaglandin F(1α), leukotriene B4, and lipoperoxidation levels in pancreatic tissue and in plasma lipase. When ischemia was induced for 30 min, nitric oxide synthase inhibition prevented these increases, and L-arginine was able to reverse this effect. By contrast, nitric oxide synthase inhibition has no effect when ischemia was prolonged for 12 hr. In summary, this study suggests that, during reperfusion, nitric oxide modulates 6-keto-prostaglandin F(1α) synthesis, lipoperoxidation levels, and the development of pancreatic injury but only when the ischemic period is quite short.
Versión del editorhttp://dx.doi.org/10.1023/A:1018824700470
URI http://hdl.handle.net/10261/114019
DOI10.1023/A:1018824700470
Identificadoresdoi: 10.1023/A:1018824700470
issn: 0163-2116
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