English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/114019
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Differential effect of nitric oxide inhibition as a function of preservation period in pancreas transplantation

AutorPi, Felip ; Hotter, Georgina ; Closa, Daniel ; Prats, Neus; Fernández-Cruz, Laureano; Badosa, Francisco; Gelpí, Emili ; Roselló-Catafau, Joan
Palabras claveleukotriene B4
transplantation
nitric oxide
pancreas
prostaglandins
free radicals
Fecha de publicación1997
EditorKluwer Academic/Plenum Publishers
CitaciónDigestive Diseases and Sciences 42(5): 962-971 (1997)
ResumenThe role of nitric oxide, produced during reperfusion as a function of preservation time, in the development of the inflammatory process in pancreas transplantation has been explored. For this purpose, the effect of nitric oxide synthase inhibition, as well as 6-keto-prostaglandin F(1α) leukotriene B4, and lipoperoxidation levels were evaluated in an experimental model of rat pancreas transplantation after different periods of cold preservation. The results show posttransplantation increases in 6-keto-prostaglandin F(1α), leukotriene B4, and lipoperoxidation levels in pancreatic tissue and in plasma lipase. When ischemia was induced for 30 min, nitric oxide synthase inhibition prevented these increases, and L-arginine was able to reverse this effect. By contrast, nitric oxide synthase inhibition has no effect when ischemia was prolonged for 12 hr. In summary, this study suggests that, during reperfusion, nitric oxide modulates 6-keto-prostaglandin F(1α) synthesis, lipoperoxidation levels, and the development of pancreatic injury but only when the ischemic period is quite short.
Versión del editorhttp://dx.doi.org/10.1023/A:1018824700470
URIhttp://hdl.handle.net/10261/114019
DOI10.1023/A:1018824700470
Identificadoresdoi: 10.1023/A:1018824700470
issn: 0163-2116
Aparece en las colecciones: (IIBB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.