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Ecdysone meets juvenile hormone: nuclear receptors seven-up and FTZ-F1 control juvenile hormone biosynthesis during hemimetabolan metamorphosis

AutorBorràs Castells, Ferran ; Nieva, Claudia ; Maestro, Óscar; Maestro, José L. ; Bellés, Xavier ; Martín Casacuberta, David A.
Fecha de publicaciónjul-2013
CitaciónInsect Hormones (19th Ecdysone) International Workshop (2013)
ResumenEcdysone and juvenile hormone (JH) are critical coordinators of normal developmental transitions in insects. In the hemimetabolous insect Blattella germanica, as in all insects, the presence of JH during juvenile development ensures that the molt will produce another juvenile instar, whereas the natural fall of this hormone in the final instar leads to the imaginal molt. Interestingly, a characteristic endocrine feature of the final nymphal instar of B. germanica is the reappearance of JH at the molt to the adult stage, as this hormone has also a major role in the regulation of reproduction. Thus, the corpora allata, whose biosynthetic activity has been impaired during the final nymphal stage, is reactivated to synthesize JH during the adult stage. Unfortunately, the mechanism that accounts for the re-­‐induction of the corpora allata biosynthetic activity at the adult molt has not been identified. Here, we show that two nuclear hormone receptors expressed in the corpora allata, BgFTZ-­‐F1 (whose expression in the gland is tightly controlled by the ecdysone-­‐dependent transcriptional cascade of nuclear hormone receptors) and seven-­‐up (BgSvp), control the stage-­‐ specific activation of the JH-­‐biosynthetic activity of the gland during the nymphal to adult transition. Animals with reduced levels of BgSvp or BgFTZ-­‐F1 presented a dramatic reduction in JH biosynthesis due to the lack of activation of several key JH-­‐biosynthesis enzymes, such as HMG-­‐CoA Synthase and HMG-­‐CoA reductase. Finally, we show that this complex cross-­‐regulatory interplay between BgSvp and BgFTZ-­‐F1 also controls JH biosynthesis during the successive gonadotrophic cycles of B. germanica.
DescripciónTrabajo presentado en el Insect Hormones (19th Ecdysone) International Workshop, celebrado en Minneapolis del 21 al 26 de julio de 2013.
URIhttp://hdl.handle.net/10261/114010
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