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Emerging concepts in liver graft preservation

AutorBejaoui, Mohamed ; Pantazi, Eirini ; Folch-Puy, Emma ; Baptista, Pedro M.; García-Gil, Agustín; Adam, René; Roselló-Catafau, Joan
Palabras claveStatic cold preservation
Suboptimal liver grafts
Preservation solutions
Graft washout solutions
Machine perfusion and liver bioengineering
Fecha de publicación14-ene-2015
EditorBaishideng Publishing Group
CitaciónWorld Journal of Gastroenteroluary 21(2): 396-407 (2015)
ResumenThe urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion (MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures (hypothermia at 4 °C, normothermia at 37 °C and subnormothermia at 20 °C-25 °C). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the “state of the art” and future perspectives in static and dynamic liver graft preservation in order to improve graft viability.
DescripciónThis article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
Versión del editorhttp://dx.doi.org/10.3748/wjg.v21.i2.396
URIhttp://hdl.handle.net/10261/114007
DOI10.3748/wjg.v21.i2.396
ISSN1007-9327
E-ISSN2219-2840
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