English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/113995
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Nuclear receptor HR4 plays an essential role in the ecdysteroid-triggered gene cascade in the development of the hemimetabolous insect Blattella germanica

AutorMané-Padrós, Daniel; Borràs Castells, Ferran ; Bellés, Xavier ; Martín Casacuberta, David A.
Palabras claveHemimetabolous insect
Blattella germanica
Nuclear receptor
Metamorphosis
20-Hydroxyecdysone
Fecha de publicación2-ene-2012
EditorElsevier
CitaciónMolecular and Cellular Endocrinology 348(1): 322-330 (2012)
ResumenDespite the differences in the developmental strategies between hemimetabolous and holometabolous insects, a common feature between both types of development is that periodic pulses of the steroid hormone 20-hydroxyecdysone (20E) dictate each developmental transition. Although the molecular action of 20E has been extensively studied in holometabolous insects, data on hemimetabolous is scarce. To address this, we have used the German cockroach Blattella germanica to show that 20E signals through a transcriptional cascade of the nuclear hormone receptor-encoding genes BgE75, BgHR3 and BgFTZ-F1. Here, we report the isolation and functional characterization of BgHR4, another nuclear receptor involved in this cascade. Expression studies along with tissue incubations and RNAi experiments show that cross-regulation between BgE75 and BgHR3 directs the expression of BgHR4. Finally, we have also shown that BgHR4 is an essential gene required for successfully completing nymphal-nymphal and nymphal-adult transitions, by allowing the appropriate delay in the induction of BgFTZ-F1. © 2011 Elsevier Ireland Ltd.
Versión del editorhttp://dx.doi.org/10.1016/j.mce.2011.09.025
URIhttp://hdl.handle.net/10261/113995
DOI10.1016/j.mce.2011.09.025
Identificadoresdoi: 10.1016/j.mce.2011.09.025
issn: 0303-7207
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.