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dc.contributor.authorMartín-García, Fernando-
dc.contributor.authorMendieta, Jesús-
dc.contributor.authorMendieta, Jesús-
dc.contributor.authorGómez-Puertas, Paulino-
dc.date.accessioned2015-04-22T09:36:51Z-
dc.date.available2015-04-22T09:36:51Z-
dc.date.issued2012-
dc.identifierdoi: 10.1016/j.bbrc.2012.02.112-
dc.identifierissn: 0006-291X-
dc.identifier.citationBiochemical and Biophysical Research Communications 420: 42- 47 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/113979-
dc.description.abstractThe fusion of paramyxovirus to the cell membrane is mediated by fusion protein (F protein) present in the virus envelope, which undergoes a dramatic conformational change during the process. Unlike hemagglutinin in orthomyxovirus, this change is not mediated by an alteration of environmental pH, and its cause remains unknown. Steered molecular dynamics analysis leads us to suggest that the conformational modification is mediated only by stretching mechanical forces once the transmembrane fusion peptide of the protein is anchored to the cell membrane. Such elongating forces will generate major secondary structure rearrangement in the heptad repeat A region of the F protein; from β-sheet conformation to an elongated coil and then spontaneously to an α-helix. In addition, it is proposed that the heptad repeat A region adopts a final three-helix coiled coil and that this structure appears after the formation of individual helices in each monomer. © 2012 Elsevier Inc.-
dc.description.sponsorshipSpanish Ministerio de Ciencia e Innovación (SAF2007-61926, IPT2011-0964-900000 and SAF2011 13156-E); the Madrid regional authority through Grant S-BIO-0260/2006-COMBACT; and the European Commission through Grants FP7 HEALTH-F3-2009-223431 (EU Project ‘‘Divinocell’’) and FP7 HEALTH-2011-278603 (EU Project ‘‘Dorian); Fundación Ramón Areces-
dc.publisherAcademic Press-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/HEALTH-F3-2009-223431-
dc.rightsopenAccess-
dc.subjectFusion protein-
dc.subjectMolecular dynamics-
dc.subjectConformational change-
dc.subjectMechanical force-
dc.titleMolecular dynamics analysis of conformational change of paramyxovirus F protein during the initial steps of membrane fusion-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbrc.2012.02.112-
dc.date.updated2015-04-22T09:36:51Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderEuropean Commission-
dc.contributor.funderFundación Ramón Areces-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
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