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dc.contributor.author | Krätzner, Ralph | - |
dc.contributor.author | Debreczeny, Judith E. | - |
dc.contributor.author | Pape, Thomas | - |
dc.contributor.author | Schneider, Thomas R. | - |
dc.contributor.author | Wentzel, Alexander | - |
dc.contributor.author | Kolmar, Harald | - |
dc.contributor.author | Sheldrick, George M. | - |
dc.contributor.author | Usón, Isabel | - |
dc.date.accessioned | 2015-04-21T09:51:36Z | - |
dc.date.available | 2015-04-21T09:51:36Z | - |
dc.date.issued | 2005-09 | - |
dc.identifier | doi: 10.1107/S0907444905021207 | - |
dc.identifier | issn: 0907-4449 | - |
dc.identifier.citation | Acta Crystallographica Section D: Biological Crystallography 61(9): 1255-1262 (2005) | - |
dc.identifier.uri | http://hdl.handle.net/10261/113909 | - |
dc.description.abstract | The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering purposes. To extend this test, the structures of two complexes of EETI-II with trypsin have also been determined, one carrying a four-amino-acid mutation of EETI-II. The remarkable similarity of these structures confirms the rigidity of the molecular framework and hence its suitability as a molecular scaffold. © 2005 International Union of Crystallography - all rights reserved. | - |
dc.description.sponsorship | This work was supported by the Deutsche Forschungsgemeinschaft (SFB416) and by the Fonds der Chemischen Industrie. IU thanks the Spanish MEC for grant BIO2003-06653 | - |
dc.publisher | Blackwell Publishing | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | knottins | - |
dc.subject | Inhibitors | - |
dc.subject | EETI-II | - |
dc.subject | molecular scaffolds | - |
dc.subject | Cystine knots | - |
dc.title | Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): A rigid molecular scaffold | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1107/S0907444905021207 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1107/S0907444905021207 | - |
dc.date.updated | 2015-04-21T09:51:36Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Kratzner-Acta-Crystallographica-D-2005-v61-n9-p1255.pdf | 1,25 MB | Adobe PDF | Visualizar/Abrir |
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