Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/113879
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Mechanism of collapse of endoplasmic reticulum cisternae during African swine fever virus infection |
Autor: | Windsor, Miriam; Hawes, Philippa; Monaghan, P.; Snapp, Erik; Salas Falgueras, María Luisa CSIC ; Rodríguez, Javier M. CSIC ORCID ; Wileman, Thomas | Palabras clave: | Viral envelope protein Cisternal collapse Endoplasmic reticulum African swine fever virus |
Fecha de publicación: | 2012 | Editor: | Blackwell Publishing | Citación: | Traffic 13: 30- 42 (2012) | Resumen: | Infection of cells with African swine fever virus (ASFV) can lead to the formation of zipper-like stacks of structural proteins attached to collapsed endoplasmic reticulum (ER) cisternae. We show that the collapse of ER cisternae observed during ASFV infection is dependent on the viral envelope protein, J13Lp. Expression of J13Lp alone in cells is sufficient to induce collapsed ER cisternae. Collapse was dependent on a cysteine residue in the N-terminal domain of J13Lp exposed to the ER lumen. Luminal collapse was also dependent on the expression of J13Lp within stacks of ER where antiparallel interactions between the cytoplasmic domains of J13Lp orientated N-terminal domains across ER cisternae. Cisternal collapse was then driven by disulphide bonds between N-terminal domains arranged in antiparallel arrays across the ER lumen. This provides a novel mechanism for biogenesis of modified stacks of ER present in cells infected with ASFV, and may also be relevant to cellular processes. © 2011 John Wiley & Sons A/S. | URI: | http://hdl.handle.net/10261/113879 | DOI: | 10.1111/j.1600-0854.2011.01293.x | Identificadores: | doi: 10.1111/j.1600-0854.2011.01293.x issn: 1398-9219 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
7
checked on 04-mar-2024
SCOPUSTM
Citations
15
checked on 27-mar-2024
WEB OF SCIENCETM
Citations
13
checked on 29-feb-2024
Page view(s)
335
checked on 28-mar-2024
Download(s)
97
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.