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A cubic arrangement of DNA double helices based on nickel-guanine interactions

AuthorsValls, Núria; Usón, Isabel ; Gouyette, Catherine; Subirana, Juan A.
Issue Date8-Jun-2004
PublisherAmerican Chemical Society
CitationJournal of the American Chemical Society 126(25): 7812-7816 (2004)
AbstractDNA oligonucleotides can be used in order to assemble highly structured materials. Oligonucleotides with sticky ends can form long linear structures, whereas branching is required to form two- and three-dimensional nanostructures. In this paper, we show that when Ni2+ is attached to the N7 atom of guanine, it can also act as a branching point. Thus, we have found that the heptanucleotide d(GAATTCG) can assemble into long linear duplex structures, which cross in space to generate a cubic structure. The three-dimensional arrays are stabilized by phosphate-Ni2+-guanine interactions. For the first time, the crystallization of a B form DNA oligonucleotide in a cubic system is reported, space group /23. Large solvent cavities are found among the DNA duplexes.
Publisher version (URL)http://dx.doi.org/10.1021/ja049393i
Identifiersdoi: 10.1021/ja049393i
issn: 0002-7863
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