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New metabolomics approaches for transgenic food analysis based on capillary electrophoresis-mass spectrometry

AutorLeón, Carlos ; García-Cañas, Virginia ; Ibáñez, Elena ; Cifuentes, Alejandro
Fecha de publicación2008
CitaciónCECE 2008
ResumenAt present, one of the principal research lines in Food Science and Technology is the development of new functional foods. A food can be considered „„functional‟‟ if, besides its nutritious effects, it can improve the state of health or well-being or reduce some disease risk. In our laboratory, we have studied for years different natural sources of functional ingredients including plants, spices, algae, etc. Nowadays, the use of genetically modified organisms (GMOs) has seen a great increase in agriculture and food industry. Thus, genetic engineering is mainly used to improve resistance of crops to plagues or pesticides. However, in the new generation of GMOs significant changes in other constituents will be deliberately introduced to generate new functional foods (e.g., increasing fatty acids, amino acids content, polyphenols, vitamins, or reducing undesirable constituents, etc), requiring the development of more powerful and informative analytical procedures. In this work, an original analytical strategy is proposed able to provide information on the composition of GMOs based on metabolomics studies carried out by capillary electrophoresis-mass spectrometry (CE-MS). The goal of this work is, therefore, to present the results from a comparative profiling study of metabolites found in transgenic varieties vs. their corresponding isogenic wild lines grown under identical conditions [1,2]. To do this, a complete analytical strategy is developed that combines metabolites extraction from samples, separation by capillary electrophoresis and chemical characterization by on-line electrospray-time of flight-mass spectrometry (CE-TOF-MS).
DescripciónTrabajo presentado al 5th international interdisciplinary meeting on bioanalysis celebrado en Brno (República Checa) del 24 al 25 de noviembre de 2008.
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