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http://hdl.handle.net/10261/113764
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Arranz, Elena | - |
dc.contributor.author | Mes, J. | - |
dc.contributor.author | Wichers, Harry J. | - |
dc.contributor.author | Jaime, Laura | - |
dc.contributor.author | Mendiola, J. A. | - |
dc.contributor.author | Reglero, Guillermo | - |
dc.contributor.author | Santoyo, Susana | - |
dc.date.accessioned | 2015-04-16T10:22:21Z | - |
dc.date.available | 2015-04-16T10:22:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Journal of Functional Foods 13: 384-390 (2015) | es_ES |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | http://hdl.handle.net/10261/113764 | - |
dc.description.abstract | The anti-inflammatory activity of the basolateral fraction of Caco-2 cells exposed to a rosemary supercritical extract was examined. Uptake of rosemary extract fractions was tested on Caco-2 cell monolayers (2-12 h incubation times) and the quantification of carnosic acid and carnosol was performed by UPLC-MS/MS. Human macrophages were treated with the basolateral fractions and secretion of TNF-α, IL-1β, IL-6 and IL-10 was measured by ELISA. The fractions obtained after 8 and 12 h in absorption experiments caused a significant reduction in excretion of the pro-inflammatory cytokines. This reduction in cytokine secretion levels corresponded to the amounts of carnosic acid and carnosol in the basolateral fractions. Thus, the basolateral fraction of a rosemary supercritical extract showed an important anti-inflammatory activity, providing the basis for increasing the use of supercritical rosemary extracts for the prevention of inflammatory diseases. | es_ES |
dc.description.sponsorship | Financial support from Spanish Ministry of Science and Innovation (CICYT) (Project: IPT-300000-2010-034), Ingredientes Saludables Mediterráneos Innovadores (INNSAMED) and Comunidad Autónoma de Madrid (ALIBIRD, project S-505/AGR-0153). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | S2013/ABI-2728/ALIBIRD-CM | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | es_ES |
dc.subject | Rosemary | es_ES |
dc.subject | Bioavailable fraction | es_ES |
dc.subject | Anti-inflammatory activity | es_ES |
dc.subject | Supercritical extraction | es_ES |
dc.title | Anti-inflammatory activity of the basolateral fraction of Caco-2 cells exposed to a rosemary supercritical extract | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.jff.2015.01.015 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jff.2015.01.015 | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología, CICYT (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007273 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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Caco-2 cells exposed.pdf | 314,84 kB | Adobe PDF | Visualizar/Abrir |
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