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Title

Looking for novel functions of tau

AuthorsÁvila, Jesús ; Gómez de Barreda, Elena ; Fuster-Matanzo, Almudena ; Simón, Diana ; Llorens-Martín, M. ; Engel, Tobías; Lucas, José Javier ; Díaz-Hernández, Miguel; Hernández Pérez, Félix
KeywordsExtracellular tau
Tau secretion
Ventral dentate gyrus
Calmodulin
Issue Date2012
PublisherPortland Press
CitationBiochemical Society Transactions 40(4): 653- 655 (2012)
AbstractThe lack or excess of the protein tau can be deleterious for neurons. The absence of tau can result in retarded neurogenesis and neuronal differentiation, although adult mice deficient in tau are viable, probably because of the compensation of the loss of tau by other MAPs (microtubule-associated proteins). On the contrary, the overexpression of tau can be toxic for the cell. One way to reduce intracellular tau levels can be achieved by its secretion through microvesicles to the extracellular space. Furthermore, tau can be found in the extracellular space because of the neuronal cell death occurring in neurodegenerative disorders such as Alzheimer’s disease. The presence of toxic extracellular tau could be the mechanism for the spreading of tau pathology in these neurodegenerative disorders.
URIhttp://hdl.handle.net/10261/113759
Identifiersissn: 0300-5127
Appears in Collections:(CBM) Artículos
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