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Título

Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes

AutorColombo, Martino; Laayouni, Hafid ; Invergo, Brandon M. ; Bertranpetit, Jaume ; Montanucci, Ludovica
Palabras claveErythrocyte metabolic network
Molecular evolution
Network dynamics
Selective pressures
Enzyme evolution
Fecha de publicaciónfeb-2014
EditorJohn Wiley & Sons
CitaciónEvolution: International Journal of Organic Evolution 68(2): 605-613 (2014)
ResumenRelationships between evolutionary rates and gene properties on a genomic, functional, pathway, or system level are being explored to unravel the principles of the evolutionary process. In particular, functional network properties have been analyzed to recognize the constraints they may impose on the evolutionary fate of genes. Here we took as a case study the core metabolic network in human erythrocytes and we analyzed the relationship between the evolutionary rates of its genes and the metabolic flux distribution throughout it. We found that metabolic flux correlates with the ratio of nonsynonymous to synonymous substitution rates. Genes encoding enzymes that carry high fluxes have been more constrained in their evolution, while purifying selection is more relaxed in genes encoding enzymes carrying low metabolic fluxes. These results demonstrate the importance of considering the dynamical functioning of gene networks when assessing the action of selection on system-level properties. © 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.
Versión del editorhttp://dx.doi.org/10.1111/evo.12262
URIhttp://hdl.handle.net/10261/113709
DOI10.1111/evo.12262
Identificadoresdoi: 10.1111/evo.12262
e-issn: 1558-5646
issn: 0014-3820
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