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Título

Recovery of betulinic acid from plane tree (Platanus acerifolia L.)

Autor Pinilla, José María; López-Padilla, Alexis; Vicente, G. ; Fornari, Tiziana ; Quintela, J. C.; Reglero, Guillermo
Palabras clave Ultrasound assisted extraction
Pressurized liquid extraction
Betulinic acid
Plane tree bark
Platanus acerifolia
Supercritical fluid extraction
Fecha de publicación 2014
EditorElsevier
Citación Journal of Supercritical Fluids 95: 541-545 (2014)
ResumenBetulinic acid (3β, hydroxy-lup-20(29)-en-28-oic acid) is a bioactive triterpenic acid which was identified in various botanical sources and in considerable amounts in the bark of plane tree (Platanus acerifolia L.). In this work, the recovery of betulinic acid from plane tree bark was studied using different liquid solvent based extraction methods, namely solid-liquid extraction (SLE), ultrasound assisted extraction (UAE) and pressurized liquid extraction (PLE). Furthermore, preliminary studies of the supercritical fluid extraction (SFE) of plane tree bark are also reported. The liquid solvent based extraction techniques (SLE, UAE and PLE) were carried out using ethanol and ethyl acetate, and produced a recovery of betulinic acid in the range 10-15 mg/g of bark, with concentrations around 25-35% mass. A betulinic acid enrichment in the ethanolic extracts was possible by means of a simple precipitation step adding water. The precipitate contained 42-46% mass of betulinic acid and high recovery (>95%). Increasing the extraction temperature, by means of the PLE assays, has not resulted in an improvement of betulinic acid recovery. The preliminary SFE assays produced lower recoveries of betulinic acid (0.5-8 mg/g) with respect to liquid extraction. The addition of ethanol as cosolvent produced a significant improvement of both betulinic acid recovery and concentration in the SFE extract.
Versión del editorhttp://dx.doi.org/10.1016/j.supflu.2014.09.001
URI http://hdl.handle.net/10261/113637
DOI10.1016/j.supflu.2014.09.001
Identificadoresdoi: 10.1016/j.supflu.2014.09.001
issn: 0896-8446
e-issn: 1872-8162
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