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dc.contributor.author | Reyes-Darias, José Antonio | - |
dc.contributor.author | Sánchez-Luque, Francisco J. | - |
dc.contributor.author | Morales, Juan C. | - |
dc.contributor.author | Pérez-Rentero, Sonia | - |
dc.contributor.author | Eritja Casadellà, Ramón | - |
dc.contributor.author | Berzal-Herranz, Alfredo | - |
dc.date.accessioned | 2015-04-10T07:18:43Z | - |
dc.date.available | 2015-04-10T07:18:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.1002/cbic.201402574 | - |
dc.identifier | issn: 1439-7633 | - |
dc.identifier.citation | Chembiochem : a European journal of chemical biology 16: 584- 591 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/113463 | - |
dc.description.abstract | © 2015 Wiley-VCH Verlag GmbH & Co. KGaA. Antisense oligodeoxynucleotides (ODNs) are short synthetic DNA polymers complementary to a target RNA sequence. They are commonly designed to halt a biological event, such as translation or splicing. ODNs are potentially useful therapeutic agents for the treatment of different human diseases. Carbohydrate-ODN conjugates have been reported to improve the cell-specific delivery of ODNs through receptor mediated endocytosis. We tested the anti-HIV activity and biochemical properties of the 5′-end glucose-conjugated GEM 91 ODN targeting the initiation codon of the gag gene of HIV-1 RNA in cell-based assays. The conjugation of a glucose residue significantly reduces the immunostimulatory effect without diminishing its potent anti-HIV-1 activity. No significant effects were observed in either ODN stability in serum, in vitro degradation of antisense DNA-RNA hybrids by RNase H, cell toxicity, cellular uptake and ability to interfere with genomic HIV-1 dimerisation. | - |
dc.publisher | John Wiley & Sons | - |
dc.rights | openAccess | - |
dc.subject | Glucose DNA oligonucleotides | - |
dc.subject | HIV-1 inhibition | - |
dc.subject | Immune response reduction | - |
dc.subject | Conjugated oligonucleotides | - |
dc.title | Glucose conjugation of anti-HIV-1 oligonucleotides containing unmethylated CpG motifs reduces their immunostimulatory activity | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1002/cbic.201402574 | - |
dc.date.updated | 2015-04-10T07:18:43Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
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