English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/113133
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorMorales, Paula-
dc.contributor.authorBlasco-Benito, S.-
dc.contributor.authorAndradas, C.-
dc.contributor.authorGómez-Cañas, María-
dc.contributor.authorFlores, Juana María-
dc.contributor.authorGoya, Pilar-
dc.contributor.authorFernández-Ruiz, Javier-
dc.contributor.authorSánchez, Cristina-
dc.contributor.authorJagerovic, Nadine-
dc.date.accessioned2015-03-30T11:59:49Z-
dc.date.available2015-03-30T11:59:49Z-
dc.date.issued2015-
dc.identifierdoi: 10.1021/acs.jmedchem.5b00078-
dc.identifierissn: 0022-2623-
dc.identifiere-issn: 1520-4804-
dc.identifier.citationJournal of Medicinal Chemistry 58: 2256- 2264 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/113133-
dc.description.abstractTriple-negative breast cancer (TNBC) represents a subtype of breast cancer characterized by high aggressiveness. There is no current targeted therapy for these patients whose prognosis, as a group, is very poor. Here, we report the synthesis and evaluation of a potent antitumor agent in vivo for this type of breast cancer designed as a combination of quinone/cannabinoid pharmacophores. This new compound (10) has been selected from a series of chromenopyrazolediones with full selectivity for the nonpsychotropic CB2 cannabinoid receptor and with efficacy in inducing death of human TNBC cell lines. The dual concept quinone/cannabinoid was supported by the fact that compound 10 exerts antitumor effect by inducing cell apoptosis through activation of CB2 receptors and through oxidative stress. Notably, it did not show either cytotoxicity on noncancerous human mammary epithelial cells nor toxic effects in vivo, suggesting that it may be a new therapeutic tool for the management of TNBC.-
dc.publisherAmerican Chemical Society-
dc.rightsclosedAccess-
dc.titleSelective, nontoxic CB2 cannabinoid o-quinone with in vivo activity against triple-negative breast cancer-
dc.typeartículo-
dc.identifier.doi10.1021/acs.jmedchem.5b00078-
dc.date.updated2015-03-30T11:59:49Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
Appears in Collections:(IQM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.