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Experimental ruminant models for bovine neosporosis: what is known and what is needed

AutorBenavides, Julio ; Collantes Fernández, E.; Ferre, Ignacio; Pérez Pérez, Valentín ; Campero, C.; Mota, R.; Innes, Elisabeth A.; Ortega Mora, Luis M.
Palabras claveHarmonization
Ruminant models
Bovine neosporosis
Knowledge gaps
Fecha de publicación2014
EditorCambridge University Press
CitaciónParasitology 141: 1471- 1488 (2014)
ResumenAt present, bovine neosporosis is an important worldwide concern because of its wide geographic distribution and economic impact. Abortion is the main clinical sign of bovine neosporosis in both dairy and beef cattle. Ruminant challenge models are critical to evaluate potential vaccine candidates to help tackle bovine neosporosis and to study pathogenesis and host responses to infection. Several research groups have developed ruminant models of Neospora caninum infection independently of others, resulting in a high degree of variability due to the use of different species of animals, breeds, strains/isolates of N. caninum, doses, routes and times of inoculation. Standardization is greatly needed to advance research in a more collaborative, timely and efficient manner. In the absence of widely accepted international guidelines, this manuscript serves to summarize and discuss the different models and parameters currently in use. Parameters essential for the development of non-pregnant and pregnant ruminant models are outlined and the main knowledge gaps are identified. This information could act as the basis to develop a consensus for international standard guidelines for ruminant models of neosporosis that would be helpful for researchers in this field worldwide.
Descripción18 páginas, 3 tablas; 1 figura.--Special Issue 11 (ApiCOWplexa 2013 – 2nd International Meeting on Apicomplexan Parasites in Farm Animals)
Versión del editorhttp://dx.doi.org/10.1017/S0031182014000638
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