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Título

The Drosophila Polycomb gene sex combs extra encodes the ortholog of mammalian RIng 1 proteins

Autor Gorfinkiel, Nicole; Fanti, Laura; Melgar, Teresa; García, Emiliano; Pimpinelli, Sergio; Vidal, Miguel
Palabras clave Drosophila ring
Sex combs extra
Ring 1A
Ring 1B
Polycomb group
Fecha de publicación 20-mar-2015
ResumenIn Drosophila the Polycomb group (PcG) of genes is required for the maintenance of homeotic gene repression during development. Here, we have characterized the Drosophila ortholog of the products of the mammalian Ring 1 = Ring 1A and Rnf 2 = Ring 1B genes. We show that Drosophila Ring corresponds to the Sex combs extra (Sce), a previously described PcG gene. We find that Ring = Sce is expressed and required throughout development and that the extreme Pc embryonic phenotype due to the lack of maternal and zygotic Sce can be rescued by ectopic expression of Ring = Sce : This phenotypic rescue is also obtained by ectopic expression of the murine Ring 1 = Ring 1A; suggesting a functional conservation of the proteins during evolution. In addition, we find that Ring/Sce binds to about 100 sites on polytene chromosomes, 70% of which overlap those of other PcG products such as Polycomb, Posterior sex combs and Polyhomeotic, and 30% of which are unique. We also show that Ring/Sce interacts directly with PcG proteins, as it occurs in mammals.
URI http://hdl.handle.net/10261/112753
DOI10.1016/j.mod.2004.03.019
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