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Somatostatin, cholecystokinin and neuropeptide Y mRNAs in normal and weaver mouse brain

AuthorsZavitsanou, Katerina; Triarhou, Lazaros Constantinos; Kouvelas, Elias D.; Mitsacos, Adamantia; Palacios, José M.; Mengod Los Arcos, Guadalupe CSIC ORCID
KeywordsmRNA expression
Issue Date1-Nov-2002
CitationJournal of Neural Transmission 109(11): 1337-1351 (2002)
AbstractThe distribution of mRNAs encoding for somatostatin, cholecystokinin and neuropeptide Y was determined by in situ hybridization histochemistry in the weaver (wv/wv) mouse, a model of dopamine deficiency as well as in normal (+/+) controls. Weaver mutants did not show any appreciable departure from the normal pattern of expression for mRNA encoding for neuropeptide Y. In contrast, an 82% increase in mRNA encoding for somatostatin was observed in the reticular thalamic nucleus, whereas increases in the order of 20-87% were observed in different hypothalamic nuclei of the weaver brain. In addition, a 47-103% increase of the hybridization signal encoding for choleocystokinin was observed in the cerebral cortex, hippocampus and thalamus of the weaver brain. It can be assumed that the elevated and region-specific somatostatin and choleocystokinin levels observed in the weaver brain may be due to a secondary or compensatory response under conditions of altered neurotransmitter levels.
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Identifiersdoi: 10.1007/s00702-002-0759-7
issn: 0300-9564
Appears in Collections:(IIBB) Artículos

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