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Serotonin 5-HT2C receptor knockout mice: Autoradiographic analysis of multiple serotonin receptors

AuthorsLópez-Giménez, Juan F. ; Tecott, Laurence H.; Palacios, José M.; Mengod Los Arcos, Guadalupe ; Vilaró, Maria Teresa
KeywordsIn situ hybridization
Mouse brain
5-HT receptors
5-HT transporter
Issue Date3-Dec-2011
PublisherJohn Wiley & Sons
CitationJournal of Neuroscience Research 67(1): 69-85 (2002)
AbstractQuantitative receptor autoradiography was used to study possible alterations of the densities of multiple serotonin (5-HT) receptor subtypes and of serotonin transporter in the brain of 5-HT2C receptor knockout mice. The radioligands employed were [3H]citalopram, [3H]WAY100,635, [3H]8-OH-DPAT, [3H]GR125743, [3H]sumatriptan, [3H]MDL100,907, [125I](=)DOI, [3H]mesulergine, [3H]5-HT, [3H]GR113808, and [3H]5-CT. As expected, radioligands that label 5-HT2C receptors showed a complete absence of labeling in mutant mice choroid plexus and significantly reduced densities in other brain regions expressing 5-HT2C receptors. With the rest of the radioligands, no significant alterations in the densities of labeled sites were found in any brain region. In situ hybridization showed no changes in 5-HT2A receptor and serotonin transporter mRNA levels, whereas 5-HT2C receptor mRNA levels were reduced in certain brain regions. The present results indicate that the mouse serotonergic system does not exhibit compensatory up- or down-regulation of the majority of its components (serotonin transporter and most 5-HT receptor subtypes) in response to the absence of 5-HT2C receptors. © 2002 Wiley-liss, Inc.
Publisher version (URL)http://dx.doi.org/10.1002/jnr.10072
Identifiersdoi: 10.1002/jnr.10072
issn: 0360-4012
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