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Título: | Localization of 5-HT receptors in the mammalian cortex |
Autor: | Santana, Noemí CSIC ORCID; Almeida, Julián de CSIC; Mengod Los Arcos, Guadalupe CSIC ORCID; Artigas, Francesc CSIC ORCID | Fecha de publicación: | 2008 | Editor: | Birkhäuser Verlag | Citación: | Serotonin and Sleep: Molecular, Functional and Clinical Aspects: 135-153 (2008) | Resumen: | erotonergic neurons located in the dorsal and median raphe nuclei innervate the whole neuraxis and are critically involved in a large number of physiological functions, including sleep. Derangements of the serotonergic system are suspected in several psychiatric disorders, including mood and anxiety disorders. A large body of data supports a prominent role of dopamine in cortical function. However, much less is known on the role of serotonin (5-HT) in the neocortex, despite a very dense serotonergic innervation of some areas, such as the frontal lobe. Among other 5-HT receptors, this area contains a high density of 5-HT1A and 5-HT2A receptors in the rodent, primate and human brains. Using double in situ hybridization, we reported on the presence of both receptor subtypes in a high proportion of pyramidal neurons and a smaller, yet significant proportion of GABAergic neurons. These data indicate that 5-HT can modulate the activity of cortical networks in a number of ways, including the activation of receptors on projection pyramidal neurons and on local inhibitory interneurons | Descripción: | Capítulo en: Jaime M. Monti; S.R. Pandi-Perumal; Barry L. Jacobs; David J. Nutts (eds.). Serotonin and Sleep: Molecular, Functional and Clinical Aspects. basel: Birckhäuser, 2008, p.135-153. ISBN 978-3-7643-8561-3. ISBN 978-3-7643-8560-6. DOI 10.1007/978-3-7643-8561-3 | Versión del editor: | http://dx.doi.org/10.1007/978-3-7643-8561-3_5 | URI: | http://hdl.handle.net/10261/112685 | DOI: | 10.1007/978-3-7643-8561-3_5 | Identificadores: | doi: 10.1007/978-3-7643-8561-3_5 isbn: 978-3-7643-8561-3 isbn: 978-3-7643-8560-6 |
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