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Increased levels of the Kunitz protease inhibitor-containing βAPP mRNAs in rat brain following neurotoxic damage

AutorSolà, Carme ; García-Ladona, F. Javier; Mengod Los Arcos, Guadalupe ; Probst, Alphonse; Frey, Peter; Palacios, José M.
Palabras claveβ-Amyloid precursor protein
β/A4
Neuronal cell damage
Kunitz protease inhibitor
Kainic acid
Alzheimer's disease
Fecha de publicaciónene-1993
EditorElsevier
CitaciónMolecular Brain Research 17(1-2): 41-52 (1993)
ResumenDeposits of β-amyloid are one of the main pathological characteristics of Alzheimer's disease. The β-amyloid peptide (or β/A4) constituent of these deposits is derived from the β-amyloid precursor protein (βAPP), which is expressed in several isoforms. It has been suggested that an imbalance in the normal ratio between the Kunitz protease inhibitor (KPI)-containing βAPPs versus the non containing forms could result in altered processing of βAPP and progressive β/A4 deposition. We have studied the expression of four βAPP isoforms in the rat brain after intracerebroventricular application of kainic acid. Increased levels of the KPI-containing βAPP and GFAP mRNAs were observed in tissues surrounding areas of neuronal damage. A parallel increase of βAPP and GFAP immunoreactivity was observed in reactive astrocytes in these areas. These results suggest that the normal ratio of βAPP isoforms may be profoundly altered as a result of neuronal damage and that non-neuronal cells may respond to neuronal injury by increased expression of the KPI-containing βAPP isoforms.
Versión del editorhttp://dx.doi.org/10.1016/0169-328X(93)90071-V
URIhttp://hdl.handle.net/10261/112682
DOI10.1016/0169-328X(93)90071-V
Identificadoresdoi: 10.1016/0169-328X(93)90071-V
issn: 0169-328X
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