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Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis

AutorTomiyama, Masahiko; Rodríguez-Puertas, Rafael; Cortés, Roser ; Pazos, Ángel ; Palacios, José M.; Mengod Los Arcos, Guadalupe
Palabras claveNeurodegenerative disease
Motor neuron disease
Glutamate
Flop
Flip
Excitotoxicity
Fecha de publicación1-jul-2002
EditorJohn Wiley & Sons
CitaciónSynapse 45(4): 245-249 (2002)
ResumenExcitotoxicity mediated by AMPA receptors has been suggested to be implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). To investigate the relevance of AMPA receptors to motor neuron degeneration in ALS, we evaluated the expression of mRNAs coding for flip and flop splice variants of AMPA receptor subunits (GluR-A to GluR-D) in the cervical segment of the spinal cord from control individuals and patients with ALS using in situ hybridization histochemistry. Transcript mRNAs coding for flop variants were significantly decreased in the ventral horn of the spinal cord from patients with ALS, whereas the mRNAs for flip variants were preserved. These findings suggest that the relative abundance of flip variants vs. flop variants is increased in spinal motor neurons of ALS patients when compared to that of control individuals. Flip variants promote assemblies of slowly desensitizing AMPA receptors. These results imply that spinal motor neurons of ALS patients possess more slowly desensitizing AMPA receptors than those of control individuals. This expression change of AMPA receptors in ALS may account for vulnerability of motor neurons in this disease. © 2002 Wiley-Liss, Inc.
Versión del editorhttp://dx.doi.org/10.1002/syn.10098
URIhttp://hdl.handle.net/10261/112678
DOI10.1002/syn.10098
Identificadoresdoi: 10.1002/syn.10098
issn: 0887-4476
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