English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/112678
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis

AuthorsTomiyama, Masahiko; Rodríguez-Puertas, Rafael; Cortés, Roser CSIC ORCID; Pazos, Ángel CSIC ORCID; Palacios, José M.; Mengod Los Arcos, Guadalupe CSIC ORCID
KeywordsNeurodegenerative disease
Motor neuron disease
Glutamate
Flop
Flip
Excitotoxicity
Issue Date1-Jul-2002
PublisherJohn Wiley & Sons
CitationSynapse 45(4): 245-249 (2002)
AbstractExcitotoxicity mediated by AMPA receptors has been suggested to be implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). To investigate the relevance of AMPA receptors to motor neuron degeneration in ALS, we evaluated the expression of mRNAs coding for flip and flop splice variants of AMPA receptor subunits (GluR-A to GluR-D) in the cervical segment of the spinal cord from control individuals and patients with ALS using in situ hybridization histochemistry. Transcript mRNAs coding for flop variants were significantly decreased in the ventral horn of the spinal cord from patients with ALS, whereas the mRNAs for flip variants were preserved. These findings suggest that the relative abundance of flip variants vs. flop variants is increased in spinal motor neurons of ALS patients when compared to that of control individuals. Flip variants promote assemblies of slowly desensitizing AMPA receptors. These results imply that spinal motor neurons of ALS patients possess more slowly desensitizing AMPA receptors than those of control individuals. This expression change of AMPA receptors in ALS may account for vulnerability of motor neurons in this disease. © 2002 Wiley-Liss, Inc.
Publisher version (URL)http://dx.doi.org/10.1002/syn.10098
URIhttp://hdl.handle.net/10261/112678
DOIhttp://dx.doi.org/10.1002/syn.10098
Identifiersdoi: 10.1002/syn.10098
issn: 0887-4476
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.