Early localization of mRNA coding for 5-HT(1A) receptors in human brain during development

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Título :	Early localization of mRNA coding for 5-HT(1A) receptors in human brain during development
Autor :	Olmo, Elena del; López-Giménez, Juan F. ; Vilaró, Maria Teresa ; Mengod Los Arcos, Guadalupe ; Palacios, José M.; Pazos, Ángel
Palabras clave :	Raphe nucleus Prenatal mRNA 5-HT(1A) receptor In situ hybridization Human brain Hippocampus Cerebellum Development
Fecha de publicación :	18-sep-1998
Editor:	Elsevier
Citación :	Molecular Brain Research 60(1): 123-126 (1998)
Resumen:	The distribution of 5-HT(1A) receptor mRNA in the human brain was studied in neonatal, children and adult cases by means of in situ hybridization histochemistry, using an oligonucleotide derived from the coding region of the human receptor. A prenatal pattern of development was observed. The hippocampus, raphe nuclei and neocortex presented high levels of hybridization already at the fetal/neonatal stage, fully comparable to the adult. A high and transient hybridization signal was found in cerebellum. These results support a role for 5-HT(1A) receptors in the regulation of neural development.
Versión del editor:	http://dx.doi.org/10.1016/S0169-328X(98)00149-1
URI :	http://hdl.handle.net/10261/112668
DOI:	10.1016/S0169-328X(98)00149-1
Identificadores:	doi: 10.1016/S0169-328X(98)00149-1 issn: 0169-328X
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