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Title

Distribution of AMPA receptor subunit mRNAs in the human basal ganglia: An in situ hybridization study

AuthorsTomiyama, Masahiko; Palacios, José M.; Cortés, Roser ; Vilaró, Maria Teresa ; Mengod Los Arcos, Guadalupe
KeywordsStriatum
Basal nucleus of Meynert
Nucleus accumbens
Glutamate receptor
Globus pallidus
Flop
Excitotoxicity
Flip
Issue Date1997
PublisherElsevier
CitationMolecular Brain Research 46(1-2): 281-289 (1997)
AbstractThe distribution of AMPA receptor subunit mRNAs (spliced flip and flop variants of GluR-A to GluR-D) in the human post-mortem striatum, nucleus accumbens, globus pallidus and basal nucleus of Meynert was determined by in situ hybridization histochemistry. In the striatum and nucleus accumbens, for each subunit, the mRNA for the flop variant was more enriched than that for the corresponding flip variant. The GluR-C(flop) mRNA was most abundant, followed by the GluR-A(flop) mRNA. Transcripts for flop forms were evenly distributed in these regions, whereas those for flip forms showed a dorsoventral increasing gradient of the hybridization signals. The signals in these areas were found to originate mainly from medium-sized neurons. In the globus pallidus, mRNAs encoding GluR-A(flop) and GluR-C(flop) were also abundantly expressed. The basal nucleus of Meynert was enriched for mRNAs of flop forms. In conclusion, AMPA receptors in these areas of the human basal ganglia appeared to be mainly composed of flop variants, especially GluR-A(flop) and GluR-C(flop). However, the finding that flip transcripts were more abundant in the nucleus accumbens than in the striatum implies differences in functions of AMPA receptors between the two regions.
Publisher version (URL)http://dx.doi.org/10.1016/S0169-328X(97)00022-3
URIhttp://hdl.handle.net/10261/112663
DOI10.1016/S0169-328X(97)00022-3
Identifiersdoi: 10.1016/S0169-328X(97)00022-3
issn: 0169-328X
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