Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/112663
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Distribution of AMPA receptor subunit mRNAs in the human basal ganglia: An in situ hybridization study |
Autor: | Tomiyama, Masahiko; Palacios, José M.; Cortés, Roser CSIC ORCID; Vilaró, Maria Teresa CSIC ORCID; Mengod Los Arcos, Guadalupe CSIC ORCID | Palabras clave: | Striatum Basal nucleus of Meynert Nucleus accumbens Glutamate receptor Globus pallidus Flop Excitotoxicity Flip |
Fecha de publicación: | 1997 | Editor: | Elsevier | Citación: | Molecular Brain Research 46(1-2): 281-289 (1997) | Resumen: | The distribution of AMPA receptor subunit mRNAs (spliced flip and flop variants of GluR-A to GluR-D) in the human post-mortem striatum, nucleus accumbens, globus pallidus and basal nucleus of Meynert was determined by in situ hybridization histochemistry. In the striatum and nucleus accumbens, for each subunit, the mRNA for the flop variant was more enriched than that for the corresponding flip variant. The GluR-C(flop) mRNA was most abundant, followed by the GluR-A(flop) mRNA. Transcripts for flop forms were evenly distributed in these regions, whereas those for flip forms showed a dorsoventral increasing gradient of the hybridization signals. The signals in these areas were found to originate mainly from medium-sized neurons. In the globus pallidus, mRNAs encoding GluR-A(flop) and GluR-C(flop) were also abundantly expressed. The basal nucleus of Meynert was enriched for mRNAs of flop forms. In conclusion, AMPA receptors in these areas of the human basal ganglia appeared to be mainly composed of flop variants, especially GluR-A(flop) and GluR-C(flop). However, the finding that flip transcripts were more abundant in the nucleus accumbens than in the striatum implies differences in functions of AMPA receptors between the two regions. | Versión del editor: | http://dx.doi.org/10.1016/S0169-328X(97)00022-3 | URI: | http://hdl.handle.net/10261/112663 | DOI: | 10.1016/S0169-328X(97)00022-3 | Identificadores: | doi: 10.1016/S0169-328X(97)00022-3 issn: 0169-328X |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
47
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
46
checked on 23-feb-2024
Page view(s)
281
checked on 17-abr-2024
Download(s)
112
checked on 17-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.