English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/112642
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 54 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Gene flow from North Africa contributes to differential human genetic diversity in southern Europe

Autor Botigué, Laura R.; Comas, David ; Bustamante, Carlos D.
Palabras clave Population genetics
Iberia
Maghreb
IBD segments
Admixture
Fecha de publicación 16-jul-2013
EditorNational Academy of Sciences (U.S.)
Citación Proceedings of the National Academy of Sciences of the USA 110(29): 11791–11796 (2013)
ResumenHuman genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the demic diffusion of agriculture from the Near East, and gene flow from Africa. Using SNP data from 2,099 individuals in 43 populations, we show that estimates of recent shared ancestry between Europe and Africa are substantially increased when gene flow from North Africans, rather than Sub-Saharan Africans, is considered. The gradient of North African ancestry accounts for previous observations of low levels of sharing with Sub-Saharan Africa and is independent of recent gene flow from the Near East. The source of genetic diversity in southern Europe has important biomedical implications; we find that most disease risk alleles from genome-wide association studies follow expected patterns of divergence between Europe and North Africa, with the principal exception of multiple sclerosis.
Descripción Botigué, Laura R. et al.
Versión del editorhttp://dx.doi.org/10.1073/pnas.1306223110
URI http://hdl.handle.net/10261/112642
DOI10.1073/pnas.1306223110
Identificadoresdoi: 10.1073/pnas.1306223110
issn: 1091-6490
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
gene_flow_from_North_Africa_Botigue.pdf503,6 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.