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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/112613
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dc.contributor.authorMolinar-Toribio, Eunice-
dc.contributor.authorPérez-Jiménez, Jara-
dc.contributor.authorJáuregui, Olga-
dc.contributor.authorMéndez, Lucía-
dc.contributor.authorMedina, Isabel-
dc.contributor.authorTorres, Josep Lluís-
dc.date.issued2015-
dc.identifier.citationBritish Journal of Nutrition 113(6): 878-887 (2015)es_ES
dc.identifier.issn0007-1145-
dc.identifier.urihttp://hdl.handle.net/10261/112613-
dc.description10 páginas, 3 figuras, 1 tabla.-- Eunice Molinar-Toribio ... et al.es_ES
dc.description.abstractThe increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stresses_ES
dc.description.sponsorshipThe present study work was supported by the Spanish Ministry of Science and Innovation and of Economy and Com- petitiveness (grant no. AGL2009-12374-C03-01, -02 and -03; AGL2013-49079-C2-1,2-R, respectively). The authors acknowl- edge the Panamanian Government (SENACYT/IFARHU) and the Spanish Ministry of Science and Innovation for their predoctoral fellowships to E. M.-T. and L. M., respectively. They also acknowledge ISCIII for the postdoctoral contract ‘Sara Borrell’ to J. P.-J. (CD09/00068). None of the funders had any role in the design, analysis and findings of the study or in the writing of this articlees_ES
dc.language.isoenges_ES
dc.publisherCambridge University Presses_ES
dc.rightsopenAccesses_ES
dc.subjectMetabolic syndromees_ES
dc.subjectn-3 PUFAes_ES
dc.subjectSpontaneously hypertensive obese ratses_ES
dc.subjectEPA/DHAes_ES
dc.titleEffect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndromees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1017/S0007114514004437-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1017/S0007114514004437es_ES
dc.identifier.e-issn1475-2662-
dc.relation.csicSíes_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeartículo-
item.grantfulltextopen-
item.languageiso639-1en-
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