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Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome

AutorMolinar-Toribio, Eunice; Pérez-Jiménez, Jara ; Jáuregui, Olga; Méndez, Lucía ; Medina, Isabel ; Torres, Josep Lluís
Palabras claveMetabolic syndrome
n-3 PUFA
Spontaneously hypertensive obese rats
Fecha de publicación2015
EditorCambridge University Press
CitaciónBritish Journal of Nutrition 113(6): 878-887 (2015)
ResumenThe increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stress
Descripción10 páginas, 3 figuras, 1 tabla.-- Eunice Molinar-Toribio ... et al.
Versión del editorhttp://dx.doi.org/10.1017/S0007114514004437
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