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Título

Immunological features of LPS from Ochrobactrum intermedium on sheep experimentally infected with Fasciola hepatica

AutorMartínez Pérez, José Manuel ; Robles Pérez, D. ; Rojo Vázquez, Francisco Antonio ; Martínez Valladares, María
Palabras claveLipopolysaccharide
Ochrobactrum intermedium
Sheep
Cytokines
IgG1
Fasciola hepatica
Fecha de publicación2014
EditorElsevier
CitaciónResearch in Veterinary Science 97: 329- 332 (2014)
ResumenThe effects of the lipopolysaccharide (LPS) from Ochrobactrum intermedium in sheep with fasciolosis was reported previously, resulting in lower fecal egg counts and fluke burden. In the current study, we analyzed its immunological effects in two groups of sheep, treated (T) and controls (C). Fasciolosis induces a T helper (Th) type-2 response, characterized by IL-4 and IL-10 production; however, at the beginning of the infection, the IFN-gamma production predominates (Th type-1 response). Although we did not find differences in IL-4 production or in the expression level of this gene in the hepatic lymph nodes, the expression level of IL-10 was higher (P < 0.05) in the T group at 4 wpi. The IFN-gamma production was higher (P < 0.01) at 12 wpi as well as its level of expression at 4 wpi (P < 0.05) in the T group. We found a higher expression level of TGF-beta at 4 wpi in the T group (P < 0.05), associated with the previous report of thicker fibrous tracks in a treated group. Immunoglobulin G1, related with a Th type-2 response, was higher (P < 0.01) in the T group at 4 and 12 wpi. In conclusion, the effects of LPS from O. intermedium could have resulted from a predominant Th type-2 immune response. (C) 2014 Elsevier Ltd. All rights reserved.
Descripción4 páginas, 1 figura, 1 tabla.
URIhttp://hdl.handle.net/10261/112563
DOI10.1016/j.rvsc.2014.07.015
ISSN0034-5288
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