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Title

Evolution of genome content: Population dynamics of transposable elements in flies and humans

AuthorsGonzález Pérez, Josefa ; Petrov, Dmitri A.
KeywordsTransposition rate
Deletion rate
Genetic draft
Genetic drift
Humans
Transposable elements
Population dynamics
Population size
Ectopic recombination
Drosophila
Issue Date7-Feb-2012
PublisherHumana Press
CitationEvolutionary Genomics 1(3): 361-383 (2012)
SeriesMethods in Molecular Biology
855
AbstractRecent research is starting to shed light on the factors that influence the population and evolutionary dynamics of transposable elements (TEs) and TE life cycles. Genomes differ sharply in the number of TE copies, in the level of TE activity, in the diversity of TE families and types, and in the proportion of old and young TEs. In this chapter, we focus on two well-studied genomes with strikingly different architectures, humans and Drosophila, which represent two extremes in terms of TE diversity and population dynamics. We argue that some of the answers might lie in (1) the larger population size and consequently more effective selection against new TE insertions due to ectopic recombination in flies compared to humans; and (2) in the faster rate of DNA loss in flies compared to humans leading to much faster removal of fixed TE copies from the fly genome. © 2012 Springer Science+Business Media, LLC.
DescriptionBook Subtitle: Statistical and Computational Methods
Publisher version (URL)http://dx.doi.org/10.1007/978-1-61779-582-4_13
URIhttp://hdl.handle.net/10261/112542
DOI10.1007/978-1-61779-582-4_13
ISBN978-1-61779-581-7
Identifiersdoi: 10.1007/978-1-61779-582-4_13
issn: 1064-3745
e-issn: 1940-6029
References978-1-61779-582-4
Appears in Collections:(IBE) Libros y partes de libros
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