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Título: | Evolution of genome content: Population dynamics of transposable elements in flies and humans |
Autor: | González Pérez, Josefa CSIC ORCID ; Petrov, Dmitri A. | Palabras clave: | Transposition rate Deletion rate Genetic draft Genetic drift Humans Transposable elements Population dynamics Population size Ectopic recombination Drosophila |
Fecha de publicación: | 7-feb-2012 | Editor: | Humana Press | Citación: | Evolutionary Genomics 1(3): 361-383 (2012) | Serie: | Methods in Molecular Biology 855 |
Resumen: | Recent research is starting to shed light on the factors that influence the population and evolutionary dynamics of transposable elements (TEs) and TE life cycles. Genomes differ sharply in the number of TE copies, in the level of TE activity, in the diversity of TE families and types, and in the proportion of old and young TEs. In this chapter, we focus on two well-studied genomes with strikingly different architectures, humans and Drosophila, which represent two extremes in terms of TE diversity and population dynamics. We argue that some of the answers might lie in (1) the larger population size and consequently more effective selection against new TE insertions due to ectopic recombination in flies compared to humans; and (2) in the faster rate of DNA loss in flies compared to humans leading to much faster removal of fixed TE copies from the fly genome. © 2012 Springer Science+Business Media, LLC. | Descripción: | Book Subtitle: Statistical and Computational Methods | Versión del editor: | http://dx.doi.org/10.1007/978-1-61779-582-4_13 | URI: | http://hdl.handle.net/10261/112542 | DOI: | 10.1007/978-1-61779-582-4_13 | ISBN: | 978-1-61779-581-7 | Identificadores: | doi: 10.1007/978-1-61779-582-4_13 issn: 1064-3745 e-issn: 1940-6029 |
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