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Activation properties of GAGA transcription factor

AuthorsVaquero, Alejandro; Blanch, Marta; Espinàs, Maria Lluïsa ; Bernués, Jordi
KeywordsGAGA factor
Glutamine-rich domain
Mechanism of activation
TATA-box mutant
Issue DateMay-2008
CitationBiochimica et Biophysica Acta - Gene Regulatory Mechanisms 1779(5): 312-317 (2008)
AbstractGAGA is a Drosophila transcription factor that has been involved in many nuclear activities. We present evidence that GAGA factor enhances transcription by stabilizing pre-initiation complex (PIC) and promoting reinitiation. Formation of PIC prior to GAGA addition prevents activation suggesting that GAGA is required early in the formation of activated complexes. GAGA stimulation of transcription can be attributed in part to a stabilization of PIC. All these properties depend on the GAGA C-terminal glutamine-rich domain and, in addition to other roles and together with previous data, support a role of GAGA as a transcription factor. © 2008 Elsevier B.V. All rights reserved
Publisher version (URL)http://dx.doi.org/10.1016/j.bbagrm.2008.02.005
Identifiersdoi: 10.1016/j.bbagrm.2008.02.005
issn: 1874-9399
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